Neuroanatomy-based matrix-guided trimming protocol for the rat brain.

@article{Defazio2015NeuroanatomybasedMT,
  title={Neuroanatomy-based matrix-guided trimming protocol for the rat brain.},
  author={Rossella Defazio and Ana Ma. Criado and Valentina Zantedeschi and Eugenio Scanziani},
  journal={Toxicologic pathology},
  year={2015},
  volume={43 2},
  pages={
          249-56
        }
}
Brain trimming through defined neuroanatomical landmarks is recommended to obtain consistent sections in rat toxicity studies. In this article, we describe a matrix-guided trimming protocol that uses channels to reproduce coronal levels of anatomical landmarks. Both setup phase and validation study were performed on Han Wistar male rats (Crl:WI(Han)), 10-week-old, with bodyweight of 298 ± 29 (SD) g, using a matrix (ASI-Instruments(®), Houston, TX) fitted for brains of rats with 200 to 400 g… CONTINUE READING

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