Neuroanatomy and pathology of sporadic Parkinson's disease.

  title={Neuroanatomy and pathology of sporadic Parkinson's disease.},
  author={Heiko Braak and Kelly del Tredici},
  journal={Advances in anatomy, embryology, and cell biology},
The proteinopathy sporadic Parkinson's disease (sPD) is the second most frequent degenerative disorder of the human nervous system after Alzheimer's disease. The alpha-synuclein inclusion body pathology (Lewy pathology) associated with sPD is distributed throughout the central, peripheral, and enteric nervous systems. The resulting nonrandom neuronal dysfunction and, in some regions, neuronal loss is reflected in a topographic distribution pattern of the Lewy pathology that, in the brain, can… CONTINUE READING


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