Neuroanatomical substrates mediating the aversive effects of D-1 dopamine receptor antagonists

@article{Shippenberg1991NeuroanatomicalSM,
  title={Neuroanatomical substrates mediating the aversive effects of D-1 dopamine receptor antagonists},
  author={T. S. Shippenberg and Regine Bals-Kubik and andrea. huber and A. Herz},
  journal={Psychopharmacology},
  year={1991},
  volume={103},
  pages={209-214}
}
An unbiased place preference conditioning procedure was used to examine the secondary reinforcing effects of selective D-1 dopamine (DA) receptor antagonists and the neuroanatomical substrates mediating these effects. Systemic administration of SCH-23390 or the non-benzazepine D-1 receptor antagonist A-69024 produced dose-related conditioned aversions for the drug-associated place. In contrast, the D-2 antagonists spiperone and (−)sulpiride were without effect. SCH-23390-induced place aversions… CONTINUE READING

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