Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice.

  title={Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice.},
  author={Jean Cosme Dodart and Chantal Mathis and Josep Saura and Kelly R. Bales and Steven M Paul and Arielle Ungerer},
  journal={Neurobiology of disease},
  volume={7 2},
Histological analyses were performed on the brains of APP(V717F) transgenic (Tg)mice previously studied in a battery of behavioral tests. We describe here the regional and age-dependent deposition of amyloid in both heterozygous and homozygous Tg mice. We also report that Tg mice show significant and age-dependent changes in synaptic density measured by synaptophysin immunoreactivity. Surprisingly, a rather marked hippocampal atrophy is observed as early as 3 months of age in Tg mice (20-40… CONTINUE READING

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