Neuroadaptation: Incubation of cocaine craving after withdrawal

  title={Neuroadaptation: Incubation of cocaine craving after withdrawal},
  author={Jeffrey W Grimm and Bruce T Hope and Roy Wise and Yavin Shaham},
Relapse to cocaine addiction is frequently associated with subjective reports of craving, a poorly understood state that precedes and accompanies cocaine-seeking behaviours. It has been suggested that over the first few weeks of withdrawal from cocaine, human addicts become sensitized to drug-associated environmental cues that act as external stimuli for craving, although the evidence for this is inconsistent. Here we provide behavioural evidence from laboratory animals suggesting that the… CONTINUE READING
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