Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.

@article{Stell2003NeuroactiveSR,
  title={Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.},
  author={Brandon M. Stell and Stephen G Brickley and Cheuk Y. Tang and Mark Farrant and Istv{\'a}n M{\'o}dy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 24},
  pages={
          14439-44
        }
}
Neuroactive steroids are potent modulators of gamma-aminobutyric acid type A receptors (GABAARs), and their behavioral effects are generally viewed in terms of altered inhibitory synaptic transmission. Here we report that, at concentrations known to occur in vivo, neuroactive steroids specifically enhance a tonic inhibitory conductance in central neurons that is mediated by extrasynaptic delta subunit-containing GABAARs. The neurosteroid-induced augmentation of this tonic conductance decreases… CONTINUE READING

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