Neuroactive steroids in periphery and cerebrospinal fluid.

  title={Neuroactive steroids in periphery and cerebrospinal fluid.},
  author={Radmila Kancheva and Martin Hill and Zdenek Novak and Jan Chrastina and Lyudmila Kancheva and Lubo{\vs} St{\'a}rka},
Some peripheral steroids penetrate the blood-brain barrier (BBB), providing at least substances for the CNS steroid metabolome. That is why the predictive value of the peripheral steroids appears to be comparable with that of the cerebrospinal fluid (CSF) steroids. The concentrations of the CSF steroids are pronouncedly lower in comparison with the ones in circulation. The available data indicate that the levels of pregnenolone sulfate substantially increase in the rat brain tissue after the… CONTINUE READING


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