Neuroactive steroids and affective disorders

  title={Neuroactive steroids and affective disorders},
  author={Daniela Eser and Cornelius Schuele and Th. C. Baghai and Elena Romeo and Rainer Rupprecht},
  journal={Pharmacology Biochemistry and Behavior},
Neuroactive steroids modulate neurotransmission through modulation of specific neurotransmitter receptors such as gamma-aminobutyric acid type A (GABA(A)) receptors. Preclinical studies suggested that neuroactive steroids may modulate anxiety and depression-related behaviour and may contribute to the therapeutical effects of antidepressant drugs. Attenuations of such neuroactive steroids have been observed during major depression and in several anxiety disorders, suggesting a pathophysiological… CONTINUE READING


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