• DOI:10.1096/fasebj.6.6.1347506
Corpus ID: 221753076

Neuroactive steroids

@article{Paul1992NeuroactiveS,
  title={Neuroactive steroids},
  author={Steven M. Paul and Robert H. Purdy},
  journal={The FASEB Journal},
  year={1992},
  volume={6},
  pages={2311 - 2322}
}

Steven M. Paul, Robert H. Purdy

Published 1992

The FASEB Journal

Neuroactive steroids are natural or synthetic steroids that rapidly alter the excitability of neurons by binding to membrane‐bound receptors such as those for inhibitory and (or) excitatory neurotransmitters. The best‐studied neuroactive steroids are a series of sedative‐hypnotic 3α‐hydroxy ring A‐reduced pregnane steroids that include the major metabolites of progesterone and deoxycorticosterone, 3α‐hydroxy‐5α‐pregnan‐20‐one (allopregnanolone) and 3α,21‐dihydroxy‐5α‐pregnan‐20‐one… CONTINUE READING

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