Neuroactive steroids: focus on human brain

  title={Neuroactive steroids: focus on human brain},
  author={Roberto Cosimo Melcangi and Giancarlo Panzica and Luis Miguel Garcia-Segura},

Neuroactive steroids, their metabolites, and neuroinflammation.

Evidence is provided supporting the hypothesis that the efficacy of neuroactive steroids could be improved through the use of their metabolites, and a crucial role of progesterone and testosterone metabolites in modulating neuroinflammation and neurodegeneration may be proposed.

Short-term effects of diabetes on neurosteroidogenesis in the rat hippocampus

Frontiers in Neuroendocrinology Sex di ff erences in steroid levels and steroidogenesis in the nervous system: Physiopathological role

The state of the art of neuroactive steroids, particularly taking in consideration sex di ff erences occurring in the synthesis and levels of these molecules is summarized.

Neuroactive steroids and their role in epilepsy

The paper reviews the biosynthesis and GABAA receptor modulation of neurosteroids and their potential role in epilepsy.

The Role of Oestrogen and Other Hormones in the Pathophysiology and Treatment of Schizophrenia

The literature reviewed in this paper suggests that hormones such as oestrogen could be a viable option, and it is hoped that with further research and larger trials, the oestrogens hypothesis can be translated into effective clinical practice.

Neuroactive Steroids and the Nervous System: Further Observations on an Incomplete Tricky Puzzle

In this special issue, we have collected reviews based on the invited lectures of the VIIth International Meeting on Steroids and Nervous System (Torino, Italy, February 2013). They cover the

Neuroactive steroid levels in plasma and cerebrospinal fluid of male multiple sclerosis patients

This study shows for the first time that the levels of several neuroactive steroids, and particularly those of progesterone and testosterone metabolites, are deeply affected in CSF of relapsing‐remitting MS male patients.

Milestones on Steroids and the Nervous System: 10 Years of Basic and Translational Research

The present review aims to recapitulate the main topics that have been presented through the various meetings of the conference on ‘Steroids and Nervous System’ and explores the impact of gonadal hormones on brain circuits and behaviour, as well as the mechanism of action of neuroactive steroids.

Editorial: Steroids and the Brain

This Research Topic aimed to collect knowledge in all aspects of steroid function in the brain from an evolutionary to physiological and pathological standpoints, which may bring new insights into steroid actions.



Acute experimental autoimmune encephalomyelitis induces sex dimorphic changes in neuroactive steroid levels

Neuroprotection by estradiol

Neurosteroid Biosynthesis in the Human Brain and Its Clinical Implications

Improved knowledge of the biochemical pathways of neurosteroidogenesis and their actions on the brain may enable new perspectives in the understanding of the physiology of the human brain as well as in the pharmacological treatment of its disturbances.

The Neurosteroid Allopregnanolone Is Reduced in Prefrontal Cortex in Alzheimer’s Disease

Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's health initiative.

The results reveal that 17beta-estradiol slows the progression of this injury and diminishes the extent of cell death by suppressing apoptotic cell death pathways and enhancing expression of genes that optimize cell survival.

Neuroactive steroids: State of the art and new perspectives

The fundamental evidence and knowledge gained constitute a profound background that offers interesting possibilities for developing effective strategies against several disorders of the nervous system, and the pleiotropic and protective abilities of neuroactive steroids.

Steroidogenic enzymes in the brain: morphological aspects.