Neuroactive steroid levels are modified in cerebrospinal fluid and plasma of post-finasteride patients showing persistent sexual side effects and anxious/depressive symptomatology.

@article{Melcangi2013NeuroactiveSL,
  title={Neuroactive steroid levels are modified in cerebrospinal fluid and plasma of post-finasteride patients showing persistent sexual side effects and anxious/depressive symptomatology.},
  author={Roberto Cosimo Melcangi and Donatella Caruso and Federico Abbiati and Silvia Giatti and Donato Calabrese and Fabrizio Piazza and Guido Cavaletti},
  journal={The journal of sexual medicine},
  year={2013},
  volume={10 10},
  pages={2598-603}
}
INTRODUCTION Observations performed in a subset of subjects treated with finasteride (an inhibitor of the enzyme 5α-reductase) for male pattern hair loss seem to indicate that sexual dysfunction as well as anxious/depressive symptomatology may occur at the end of the treatment and continue after discontinuation. AIM A possible hypothesis to explain depression symptoms after finasteride treatment might be impairment in the levels of neuroactive steroids. Therefore, neuroactive steroid levels… CONTINUE READING

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