Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients

  title={Neuroactive steroid levels and psychiatric and andrological features in post-finasteride patients},
  author={R. Melcangi and D. Santi and R. Spezzano and M. Grimoldi and G. Cavaletti},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • R. Melcangi, D. Santi, +2 authors G. Cavaletti
  • Published 2017
  • Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • Recent reports show that, in patients treated with finasteride for male pattern hair loss, persistent side effects including sexual side effects, depression, anxiety and cognitive complaints may occur. [...] Key Result We found that eight out of sixteen PFS male patients considered suffered from a DSM-IV major depressive disorder (MDD). In addition, all PFS patients showed erectile dysfunction (ED); in particular, ten patients showed a severe and six a mild-moderate ED.Expand Abstract
    47 Citations
    Post-finasteride Syndrome: A Review of Current Literature
    • 1
    Post-finasteride syndrome: An emerging clinical problem
    • 10
    • Highly Influenced
    Post-finasteride syndrome: a surmountable challenge for clinicians.
    • 6
    Enduring sexual dysfunction after treatment with antidepressants, 5α-reductase inhibitors and isotretinoin: 300 cases
    • 25
    • PDF
    Finasteride and androgenic alopecia; from therapeutic options to medical implications
    • 2


    Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma
    • 60
    Neuroactive steroid levels are modified in cerebrospinal fluid and plasma of post-finasteride patients showing persistent sexual side effects and anxious/depressive symptomatology.
    • 66
    Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride
    • 68
    Emotional Consequences of Finasteride: Fool’s Gold
    • 23
    Depression Circumstantially Related to the Administration of Finasteride for Androgenetic Alopecia
    • 83
    Finasteride adverse effects in subjects with androgenic alopecia: A possible therapeutic approach according to the lateralization process of the brain
    • 24
    Finasteride induced depression: a prospective study
    • 93
    • PDF
    Inhibitors of 5α-reductase-related side effects in patients seeking medical care for sexual dysfunction
    • 24
    Depressive symptoms and suicidal thoughts among former users of finasteride with persistent sexual side effects.
    • M. Irwig
    • Psychology, Medicine
    • The Journal of clinical psychiatry
    • 2012
    • 114