Neuroactive diol and acyloin metabolites from cone snail-associated bacteria.

  title={Neuroactive diol and acyloin metabolites from cone snail-associated bacteria.},
  author={Zhenjian Lin and Lenny Marett and Ronald W. Hughen and Malem S Flores and Imelda Forteza and Mary Anne Ammon and Gisela P. Concepcion and Samuel S Espino and Baldomero M Olivera and Gary Rosenberg and Margo G. Haygood and Alan R. Light and Eric W Schmidt},
  journal={Bioorganic & medicinal chemistry letters},
  volume={23 17},
The bacterium Gordonia sp. 647W.R.1a.05 was cultivated from the venom duct of the cone snail, Conus circumcisus. The Gordonia sp. organic extract modulated the action potential of mouse dorsal root ganglion neurons. Assay-guided fractionation led to the identification of the new compound circumcin A (1) and 11 known analogs (2-12). Two of these compounds… CONTINUE READING