Neuroactive Steroids and Human Recombinant ρ1 GABA Receptors

@article{Li2007NeuroactiveSA,
  title={Neuroactive Steroids and Human Recombinant $\rho$1 GABA Receptors},
  author={Wenjun Li and Xiaochun Jin and Douglas F Covey and Joe Henry Steinbach},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2007},
  volume={323},
  pages={236 - 247}
}
  • Wenjun Li, X. Jin, +1 author J. Steinbach
  • Published 1 October 2007
  • Biology, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
The γ-aminobutyric acid type C (GABAC) receptor is structurally related to the GABAA receptors, yet quite distinct physiologically and pharmacologically. Neuroactive steroids are known to be potent and efficacious modulators of the GABAA receptor, but they are less well characterized in their actions on the GABAC receptor. We have examined the actions of neuroactive steroids and analogs on ρ1 (GABAC) receptors expressed in Xenopus laevis oocytes, with two goals in mind. First, we tested a… Expand
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