Neuroactive Steroids: Receptor Interactions and Responses

  title={Neuroactive Steroids: Receptor Interactions and Responses},
  author={Kald Beshir Tuem and Tesfay Mehari Atey},
  booktitle={Front. Neurol.},
Neuroactive steroids (NASs) are naturally occurring steroids, which are synthesized centrally as de novo from cholesterol and are classified as pregnane, androstane, and sulfated neurosteroids (NSs). NASs modulate many processes via interacting with gamma-aminobutyric acid (GABA), N-methyl-d-aspartate, serotonin, voltage-gated calcium channels, voltage-dependent anion channels, α-adrenoreceptors, X-receptors of the liver, transient receptor potential channels, microtubule-associated protein 2… CONTINUE READING