Neuroactive Steroid Actions at the GABAA Receptor

  title={Neuroactive Steroid Actions at the GABAA Receptor},
  author={Nancy C. Lan and Kelvin W. Gee},
  journal={Hormones and Behavior},
  • N. LanK. Gee
  • Published 1 December 1994
  • Biology, Chemistry
  • Hormones and Behavior
Neuroactive steroids are a new class of steroids that do not interact with any of the classical cytosolic hormonal steroid receptors. The most well-documented examples are those that interact with the gamma-aminobutyric acidA (GABAA) receptor/chloride channel complex in the central nervous system. The GABAA receptors are known to contain allosteric modulatory sites for therapeutically useful drugs such as benzodiazepines (BZs) and barbiturates. The interaction of neuroactive steroids with the… 

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