Neuroactive Steroid Actions at the GABAA Receptor

  title={Neuroactive Steroid Actions at the GABAA Receptor},
  author={N. C. Lan and K. Gee},
  journal={Hormones and Behavior},
  • N. C. Lan, K. Gee
  • Published 1994
  • Chemistry, Medicine
  • Hormones and Behavior
  • Neuroactive steroids are a new class of steroids that do not interact with any of the classical cytosolic hormonal steroid receptors. The most well-documented examples are those that interact with the gamma-aminobutyric acidA (GABAA) receptor/chloride channel complex in the central nervous system. The GABAA receptors are known to contain allosteric modulatory sites for therapeutically useful drugs such as benzodiazepines (BZs) and barbiturates. The interaction of neuroactive steroids with the… CONTINUE READING
    68 Citations
    Effects of PKC activation and receptor desensitization on neurosteroid modulation of GABA(A) receptors.
    • 104
    Potentiated modulation of pregnolone on GABAA receptors in behaviorally stressed borderline-hypertensive rats.
    • PDF
    Behaviorally Selective Effects of Neuroactive Steroids on Plus-Maze Anxiety in Mice
    • 132
    Estradiol Synthesis and Action at the Synapse: Evidence for “Synaptocrine” Signaling
    • 40
    • PDF