NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition

@inproceedings{Osborne2013NeuroD1RO,
  title={NeuroD1 regulation of migration accompanies the differential sensitivity of neuroendocrine carcinomas to TrkB inhibition},
  author={Jihan K. Osborne and Jill Everland Larsen and Joshua X. Gonzales and David S. Shames and Masae Sato and Ignacio Wistuba and Luc Girard and John D. Minna and Melanie H Cobb},
  booktitle={Oncogenesis},
  year={2013}
}
The developmental transcription factor NeuroD1 is anomalously expressed in a subset of aggressive neuroendocrine tumors. Previously, we demonstrated that TrkB and neural cell adhesion molecule (NCAM) are downstream targets of NeuroD1 that contribute to the actions of neurogenic differentiation 1 (NeuroD1) in neuroendocrine lung. We found that several malignant melanoma and prostate cell lines express NeuroD1 and TrkB. Inhibition of TrkB activity decreased invasion in several neuroendocrine… CONTINUE READING