NeuroD Factors Discriminate Mineralocorticoid From Glucocorticoid Receptor DNA Binding in the Male Rat Brain.

@article{Weert2017NeuroDFD,
  title={NeuroD Factors Discriminate Mineralocorticoid From Glucocorticoid Receptor DNA Binding in the Male Rat Brain.},
  author={Lisa T C M van Weert and Jacobus C Buurstede and Ahmed Y. Mahfouz and Pamela S M Braakhuis and J Annelies E Polman and Hetty C M Sips and Benno Roozendaal and Judit Balog and E. Ronald de Kloet and Nicole A Datson and Onno C. Meijer},
  journal={Endocrinology},
  year={2017},
  volume={158 5},
  pages={1511-1522}
}
In the limbic brain, mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) both function as receptors for the naturally occurring glucocorticoids (corticosterone/cortisol) but mediate distinct effects on cellular physiology via transcriptional mechanisms. The transcriptional basis for specificity of these MR- vs GR-mediated effects is unknown. To address this conundrum, we have identified the extent of MR/GR DNA-binding selectivity in the rat hippocampus using chromatin… CONTINUE READING
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