Neuro-oncology of Neurofibromatosis Type 1.

  title={Neuro-oncology of Neurofibromatosis Type 1.},
  author={Andreas F. Hottinger and Yasmin N Khakoo},
  journal={Current treatment options in neurology},
  volume={11 4},
Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder with an incidence of about 1:2500 to 1:3000. It is caused by a germline inactivating mutation of the NF1 gene on chromosome 17. Patients with NF1 are at increased risk of developing a variety of tumors of the peripheral and central nervous system, including neurofibromas, plexiform neurofibromas, malignant peripheral nerve sheath tumors, and low-grade gliomas of the optic nerves and other cerebral structures. Rarely, they develop… CONTINUE READING