Neuro-oncology, a decade of temozolomide and beyond.

@article{Stupp2010NeurooncologyAD,
  title={Neuro-oncology, a decade of temozolomide and beyond.},
  author={Roger Stupp and Monika E Hegi and Michael Weller},
  journal={Expert review of anticancer therapy},
  year={2010},
  volume={10 11},
  pages={1675-7}
}
It has been a decade since the regulatory approval of temozolomide, the first drug specifically developed for the treatment of malignant glioma. Initially, only a conditional approval was granted by the US FDA based on a high radiological response rate in recurrent anaplastic astrocytoma, while in glioblastoma the observed responses in two pivotal studies were only 5 and 8%, respectively [1–3]. Nevertheless, the clinical observation that disease stabilization may be clinically relevant in this… CONTINUE READING

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