Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

  title={Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages},
  author={Ilana Gabanyi and Paul Andrew Muller and Linda M. Feighery and Thiago Y. K. Oliveira and Frederico Azevedo Costa-Pinto and Daniel Mucida},
Proper adaptation to environmental perturbations is essential for tissue homeostasis. In the intestine, diverse environmental cues can be sensed by immune cells, which must balance resistance to microorganisms with tolerance, avoiding excess tissue damage. By applying imaging and transcriptional profiling tools, we interrogated how distinct microenvironments in the gut regulate resident macrophages. We discovered that macrophages exhibit a high degree of gene-expression specialization dependent… CONTINUE READING
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