Neuro-endocrine-immune axis in human rheumatoid arthritis.

  title={Neuro-endocrine-immune axis in human rheumatoid arthritis.},
  author={Tsuyoshi Sakane and Noboru Suzuki},
  journal={Archivum immunologiae et therapiae experimentalis},
  volume={48 5},
We present an overview of the role of neuro-endocrine-immune mechanisms in the pathophysiological responses of patients with rheumatoid arthritis (RA). In patients with RA, proinflammatory cytokines secreted by synovial cells provoke local inflammation in the joints and, simultaneously, initiate a systemic acute phase response. Thus, profound changes of the neuro-endocrine-immune axis could take place in the patients. Defects in the hypothalamus-pituitary-adrenal axis have been observed in… CONTINUE READING