Neuro- and cardioprotective effects of blockade of nitric oxide action by administration of methylene blue.

@article{Wiklund2007NeuroAC,
  title={Neuro- and cardioprotective effects of blockade of nitric oxide action by administration of methylene blue.},
  author={Lennart Wiklund and Samar Basu and Adriana A Miclescu and Per Gunnar Wiklund and Gunnar Ronquist and Hari Shanker Sharma},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1122},
  pages={
          231-44
        }
}
Methylene blue (MB), generic name methylthioninium (C(16)H(18)ClN(3) S . 3H(2)O), is a blue dye synthesized in 1876 by Heinrich Caro for use as a textile dye and used in the laboratory and clinically since the 1890s, with well-known toxicity and pharmacokinetics. It has experimentally proven neuroprotective and cardioprotective effects in a porcine model of global ischemia-reperfusion in experimental cardiac arrest. This effect has been attributed to MB's blocking effect on nitric oxide… CONTINUE READING
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