Neuritic regeneration and synaptic reconstruction induced by withanolide A.

@article{Kuboyama2005NeuriticRA,
  title={Neuritic regeneration and synaptic reconstruction induced by withanolide A.},
  author={Tomoharu Kuboyama and Chihiro Tohda and Katsuko Komatsu},
  journal={British journal of pharmacology},
  year={2005},
  volume={144 7},
  pages={961-71}
}
We investigated whether withanolide A (WL-A), isolated from the Indian herbal drug Ashwagandha (root of Withania somnifera), could regenerate neurites and reconstruct synapses in severely damaged neurons. We also investigated the effect of WL-A on memory-deficient mice showing neuronal atrophy and synaptic loss in the brain. Axons, dendrites, presynapses, and postsynapses were visualized by immunostaining for phosphorylated neurofilament-H (NF-H), microtubule-associated protein 2 (MAP2… CONTINUE READING