Neuritic regeneration and synaptic reconstruction induced by withanolide A

  title={Neuritic regeneration and synaptic reconstruction induced by withanolide A},
  author={Tomoharu Kuboyama and Chihiro Tohda and Katsuko Komatsu},
  journal={British Journal of Pharmacology},
1 We investigated whether withanolide A (WL‐A), isolated from the Indian herbal drug Ashwagandha (root of Withania somnifera), could regenerate neurites and reconstruct synapses in severely damaged neurons. We also investigated the effect of WL‐A on memory‐deficient mice showing neuronal atrophy and synaptic loss in the brain. Axons, dendrites, presynapses, and postsynapses were visualized by immunostaining for phosphorylated neurofilament‐H (NF‐H), microtubule‐associated protein 2 (MAP2… 
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Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha
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Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1).
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Cholesterol‐dependent modulation of dendrite outgrowth 
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Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
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    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
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Substrate‐Bound β‐Amyloid Peptides Inhibit Cell Adhesion and Neurite Outgrowth in Primary Neuronal Cultures
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