Neuritic regeneration and synaptic reconstruction induced by withanolide A

@article{Kuboyama2005NeuriticRA,
  title={Neuritic regeneration and synaptic reconstruction induced by withanolide A},
  author={Tomoharu Kuboyama and Chihiro Tohda and Katsuko Komatsu},
  journal={British Journal of Pharmacology},
  year={2005},
  volume={144}
}
1 We investigated whether withanolide A (WL‐A), isolated from the Indian herbal drug Ashwagandha (root of Withania somnifera), could regenerate neurites and reconstruct synapses in severely damaged neurons. We also investigated the effect of WL‐A on memory‐deficient mice showing neuronal atrophy and synaptic loss in the brain. Axons, dendrites, presynapses, and postsynapses were visualized by immunostaining for phosphorylated neurofilament‐H (NF‐H), microtubule‐associated protein 2 (MAP2… 
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References

SHOWING 1-10 OF 52 REFERENCES
Dendrite extension by methanol extract of Ashwagandha (roots of Withania somnifera) in SK‐N‐SH cells
TLDR
It is found that the methanol extract of Ashwagandha significantly increased the percentage of cells with neurites in human neuroblastoma SK-N-SH cells and Immunocytochemistry demonstrated the specific expression of MAP2 in neurites extended by the extract.
Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha
TLDR
It is found that six of the 18 compounds isolated from the methanol extract enhanced neurite outgrowth in human neuroblastoma SH-SY5Y cells, and axons are predominantly extended by withanolide A, and dendrites by withanosides IV and VI.
Neurotrophic and neuroprotective actions of ginsenosides Rb(1) and Rg(1).
TLDR
The results suggest that these two ginsenosides have neurotrophic and selective neuroprotective actions that may contribute to the purported enhancement of cognitive function.
Cholesterol‐dependent modulation of dendrite outgrowth 
and microtubule stability in cultured neurons
TLDR
It is proposed that cholesterol‐deficiency causes a selective inhibition of dendrite outgrowth due to the decreased stability of microtubules as a result of inhibition of MAP2 phosphorylation.
Aβ(25–35)-Induced Memory Impairment, Axonal Atrophy, and Synaptic Loss are Ameliorated by M1, A Metabolite of Protopanaxadiol-Type Saponins
TLDR
M1 was shown to be effective in vitro and in vivo, indicating that Ginseng drugs containing protopanaxadiol (ppd)-type saponins may reactivate neuronal function in AD by p.o.v. administration.
Neurotrophins promote maturation of developing neuromuscular synapses
  • T. Wang, K. Xie, B. Lu
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
Results suggest that BDNF and NT- 3 promote functional maturation of synapses in Xenopus nerve-muscle cocultures, primarily through a presynaptic mechanism.
Neuroaxonal pathology in Creutzfeldt-Jakob disease
TLDR
It is concluded that neuroaxonal pathology is a frequent and important part of brain lesioning in CJD, probably reflecting profound impairment of axonal transport.
Glutamate and Amyloid β-Protein Rapidly Inhibit Fast Axonal Transport in Cultured Rat Hippocampal Neurons by Different Mechanisms
TLDR
It is suggested that glutamate inhibits axonal transport via activation of NMDA and AMPA receptors and Ca2+ influx, whereas Aβ exerts its inhibitory effect via actin polymerization and aggregation, which is probably present in the 31-35 sequence.
Substrate‐Bound β‐Amyloid Peptides Inhibit Cell Adhesion and Neurite Outgrowth in Primary Neuronal Cultures
TLDR
The results suggest that accumulation of Aβ may disrupt cell‐adhesion mechanisms in vivo, and specifically on neurite outgrowth and synaptogenesis in isolated chick sympathetic and mouse cortical neurons.
...
...