Neuritic growth from a new subline of PC12 pheochromocytoma cells: cyclic AMP mimics the action of nerve growth factor.

@article{KatohSemba1987NeuriticGF,
  title={Neuritic growth from a new subline of PC12 pheochromocytoma cells: cyclic AMP mimics the action of nerve growth factor.},
  author={Ritsuko Katoh-Semba and Sakihito Kitajima and Yoshihito Yamazaki and Masakazu Sano},
  journal={Journal of neuroscience research},
  year={1987},
  volume={17 1},
  pages={36-44}
}
We have identified a new subline of PC12 pheochromocytoma cells (PC12D cells) in which neurites are extended within 24 hr in response to cAMP-enhancing reagents as well as in response to nerve growth factor (NGF), but not in response to epidermal growth factor or phorbol diester. Anti-NGF antiserum did not affect forskolin (FRK)-induced neuritic recruitment. FRK-induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with… CONTINUE READING

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FRK - induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with NGF - induced neurites .
FRK - induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with NGF - induced neurites .
FRK - induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with NGF - induced neurites .
FRK - induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with NGF - induced neurites .
FRK - induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with NGF - induced neurites .
FRK - induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with NGF - induced neurites .
FRK - induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with NGF - induced neurites .
FRK - induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with NGF - induced neurites .
FRK - induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with NGF - induced neurites .
FRK - induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with NGF - induced neurites .
FRK - induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with NGF - induced neurites .
FRK - induced neurites exhibited growth cones and contained secretion granules and many parallel arrays of microtubules as was the case with NGF - induced neurites .
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