Neurite-promoting effect of alpha 2-macroglobulin in rat cerebral cortex is mainly associated with alpha 2-macroglobulin receptor.

Abstract

It has been reported that alpha 2-macroglobulin (alpha 2 M), known as a plasma protease inhibitor, promotes neurite outgrowth of cultured neurons from rat cerebral cortex. The neurons dissociated from 17-day embryonic (E17) rat cerebral cortex were cultured in the medium containing methylamine-modified alpha 2M labeled with fluorescein isothiocyanate (MA… (More)

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