Neurite outgrowth induced by cyclic AMP can be modulated by the alpha subunit of Go.

@article{Ghil2000NeuriteOI,
  title={Neurite outgrowth induced by cyclic AMP can be modulated by the alpha subunit of Go.},
  author={Sung Ho Ghil and Bum Joon Kim and Young Don Lee and Haeyoung Suh-Kim},
  journal={Journal of neurochemistry},
  year={2000},
  volume={74 1},
  pages={151-8}
}
Although abundant Go has been found in nervous tissues and it has been implicated in neuronal differentiation, the mechanism of how Go modulates neuronal differentiation has not been defined. Here, we report that the alpha subunit of Go (alphao) modulates neurite outgrowth by interfering with the signaling pathway initiated by cyclic AMP (cAMP). In F11 cells, cAMP induced neurite outgrowth and activated cAMP-responsive element binding protein (CREB). Specific inhibition of cAMP-dependent… CONTINUE READING

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