Neurite outgrowth in peripherin-depleted PC12 cells

  title={Neurite outgrowth in peripherin-depleted PC12 cells},
  author={Carol Troy and Lloyd A Greene and Michael L Shelanski},
  journal={The Journal of Cell Biology},
  pages={1085 - 1092}
Peripherin is the major neuronal intermediate filament (IF) protein in PC12 cells and both its synthesis and amount increase during nerve growth factor (NGF) promoted neuronal differentiation. To address the question of the biological function of peripherin in neurite initiation we have used an antisense oligonucleotide complementary to the 5' region of peripherin mRNA to specifically inhibit its transcription. The oligonucleotide blocks both the synthesis of peripherin and its increase in… CONTINUE READING
17 Extracted Citations
38 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 17 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 38 references

Relationship between the nerve growth factor-regulated clone 73 gene product and the 58-kilodalton neuronal intermediate filament protein (peripherin)

  • Aletta, M. L, +4 authors L. A. Greene.
  • J. Neurochem. 4:1317-1320.
  • 1988
Highly Influential
7 Excerpts

199 I . Cellular and molecular biology of neuronal intermediate filaments

  • I. S. Gcorgieff, R. K. H. Liem, W. Mellado, J. Nunez, M. L. Shelanski
  • In Internat ' l Rev of Cytology .
  • 1991

Similar Papers

Loading similar papers…