Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity.

@article{Ryan2016NeuriteOI,
  title={Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity.},
  author={Kristen R. Ryan and Oksana Sirenko and Frederick M. Parham and Jui-Hua Hsieh and Evan F. Cromwell and Raymond Richard Tice and Mamta Behl},
  journal={Neurotoxicology},
  year={2016},
  volume={53},
  pages={271-281}
}
Due to the increasing prevalence of neurological disorders and the large number of untested compounds in the environment, there is a need to develop reliable and efficient screening tools to identify environmental chemicals that could potentially affect neurological development. Herein, we report on a library of 80 compounds screened for their ability to inhibit neurite outgrowth, a process by which compounds may elicit developmental neurotoxicity, in a high-throughput, high-content assay using… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Multi-behavioral endpoint testing of an 87-chemical compound library in freshwater planarians.

Toxicological sciences : an official journal of the Society of Toxicology • 2018
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Use of neural models of proliferation and neurite outgrowth to screen environmental chemicals in the ToxCast Phase 1 library. Applied in vitro toxicology

NM Radio, JM Breier, +3 authors KA Houck
2015
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…