Neurite outgrowth activity of cyathane diterpenes from Sarcodon cyrneus, cyrneines A and B.

@article{Marcotullio2006NeuriteOA,
  title={Neurite outgrowth activity of cyathane diterpenes from Sarcodon cyrneus, cyrneines A and B.},
  author={Maria Carla Marcotullio and Rita Pagiott and Federica Maltese and Yutaro Obara and Tomohiro Hoshino and Norimichi Nakahata and Massimo Curini},
  journal={Planta medica},
  year={2006},
  volume={72 9},
  pages={819-23}
}
Two new cyathane diterpenes, cyrneines A (1) and B (2), were isolated from the mushroom Sarcodon cyrneus. The structures of the novel diterpenoids were determined by analysis of their spectroscopic data. Neither cyrneine A nor cyrneine B at 100 microM showed cytotoxicity as determined by LDH analysis. The stimulating activity on neurite outgrowth of cyrneines was evaluated. Rat pheochromocytoma cells (PC12), used as a model system of neuronal differentiation, were cultured with cyrneine A (100… CONTINUE READING