Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment

@article{Humphries1988NeuriteEO,
  title={Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment},
  author={Martin J Humphries and Steven K. Akiyama and Akira Komoriya and Kenneth Olden and Kenneth M Yamada},
  journal={The Journal of Cell Biology},
  year={1988},
  volume={106},
  pages={1289 - 1297}
}
Fibronectin contains at least two domains that support cell adhesion. One is the central cell-binding domain that is recognized by a variety of cell types, including fibroblasts. The second, originally identified by its ability to support melanoma cell adhesion, is located in the alternatively spliced type III connecting segment (IIICS). Using specific adhesive ligands and inhibitory probes, we have examined the role of each of these domains in fibronectin-mediated neurite extension of neurons… CONTINUE READING
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