Neuregulins stimulate the functional expression of Ca2+-activated K+ channels in developing chicken parasympathetic neurons.

@article{Subramony1997NeuregulinsST,
  title={Neuregulins stimulate the functional expression of Ca2+-activated K+ channels in developing chicken parasympathetic neurons.},
  author={Priya Subramony and Stuart E Dryer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 11},
  pages={5934-8}
}
The developmental expression of macroscopic Ca2+-activated K+ currents (IK[Ca]) in chicken ciliary ganglion (CG) neurons is dependent in part on trophic factors released from preganglionic nerve terminals. Neuregulins are expressed in the preganglionic neurons that innervate the chicken CG and are therefore plausible candidates for this activity. Application of 1 nM beta1-neuregulin peptide for 12 hr evokes a large (7- to 10-fold) increase in IK[Ca] in embryonic day 9 CG neurons, even in the… CONTINUE READING

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