Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury

@article{Bersell2009Neuregulin1ErbB4SI,
  title={Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury},
  author={K. Bersell and S. Arab and B. Haring and B. K{\"u}hn},
  journal={Cell},
  year={2009},
  volume={138},
  pages={257-270}
}
Many organs rely on undifferentiated stem and progenitor cells for tissue regeneration. Whether differentiated cells themselves can contribute to cell replacement and tissue regeneration is a controversial question. Here, we show that differentiated heart muscle cells, cardiomyocytes, can be induced to proliferate and regenerate. We identify an underlying molecular mechanism for controlling this process that involves the growth factor neuregulin1 (NRG1) and its tyrosine kinase receptor, ErbB4… Expand
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References

SHOWING 1-10 OF 40 REFERENCES
Neuregulin-1 enhances differentiation of cardiomyocytes from embryonic stem cells
  • 31
Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair
  • 550
Heterogeneous proliferative potential in regenerative adult newt cardiomyocytes
  • 129
  • PDF
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes.
  • 508
  • PDF
FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction
  • 284
  • Highly Influential
  • PDF
Cardiac myocyte cell cycle control in development, disease, and regeneration.
  • 473
  • PDF
Cyclin A2 Mediates Cardiomyocyte Mitosis in the Postmitotic Myocardium*
  • 172
  • PDF
Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury
  • 730
  • PDF
...
1
2
3
4
...