• DOI:10.1016/j.cell.2009.04.060
Corpus ID: 14202454

Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury

@article{Bersell2009Neuregulin1ErbB4SI,
  title={Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury},
  author={K. Bersell and S. Arab and B. Haring and B. K{\"u}hn},
  journal={Cell},
  year={2009},
  volume={138},
  pages={257-270}
}

• K. Bersell, S. Arab, +1 author B. Kühn
• Published 2009
• Biology, Medicine
• Cell

Many organs rely on undifferentiated stem and progenitor cells for tissue regeneration. Whether differentiated cells themselves can contribute to cell replacement and tissue regeneration is a controversial question. Here, we show that differentiated heart muscle cells, cardiomyocytes, can be induced to proliferate and regenerate. We identify an underlying molecular mechanism for controlling this process that involves the growth factor neuregulin1 (NRG1) and its tyrosine kinase receptor, ErbB4… Expand

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