Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors.

@article{Rohrbach1999NeuregulinIC,
  title={Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors.},
  author={S Rohrbach and Xinhua Yan and Ellen O. Weinberg and Faisal Hasan and Jozef J. Bartunek and Mark A. Marchionni and Beverly H. Lorell},
  journal={Circulation},
  year={1999},
  volume={100 4},
  pages={407-12}
}
BACKGROUND Neuregulins are a family of peptide growth factors that promote cell growth and viability. The potential role of neuregulin-erbB signaling in hypertrophic growth and later failure in the adult heart in vivo is not known. METHODS AND RESULTS We used ribonuclease protection assays to quantify mRNA levels of neuregulin, erbB2, and erbB4 in left ventricular (LV) tissue and myocytes of normal rats and rats with aortic stenosis with pressure-overload hypertrophy 6 and 22 weeks after… CONTINUE READING