Neuregulin expression at neuromuscular synapses is modulated by synaptic activity and neurotrophic factors.

@article{Loeb2002NeuregulinEA,
  title={Neuregulin expression at neuromuscular synapses is modulated by synaptic activity and neurotrophic factors.},
  author={Jeffrey A. Loeb and Abdelkrim Hmadcha and Gerald D. Fischbach and Susan J. Land and Vaagn L Zakarian},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 6},
  pages={2206-14}
}
The proper formation of neuromuscular synapses requires ongoing synaptic activity that is translated into complex structural changes to produce functional synapses. One mechanism by which activity could be converted into these structural changes is through the regulated expression of specific synaptic regulatory factors. Here we demonstrate that blocking synaptic activity with curare reduces synaptic neuregulin expression in a dose-dependent manner yet has little effect on synaptic agrin or a… CONTINUE READING

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