Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo.

@article{Bernard2012Neuregulin4IA,
  title={Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo.},
  author={Jessica K. Bernard and Sean Patrick McCann and Vrinda Bhardwaj and Mary Kay Washington and Mark R Frey},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 47},
  pages={
          39850-8
        }
}
Expression of the ErbB4 tyrosine kinase is elevated in colonic epithelial cells during inflammatory bowel disease, whereas ErbB4 overexpression in cultured colonocytes blocks TNF-induced apoptosis in a ligand-dependent manner. Together, these observations suggest that ErbB4 induction may be a protective response. However, the effects of ErbB4 signaling in the colonic epithelium in vivo are not known. Furthermore, previous work on ErbB4 used ligands shared with other receptors, raising the… CONTINUE READING
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