Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

@article{Carraway1997Neuregulin2AN,
  title={Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases},
  author={Kermit L. Carraway and Janet L. Weber and Michelle J. Unger and Jessica Ledesma and Naichen Yu and Martin Gassmann and Cary Lai},
  journal={Nature},
  year={1997},
  volume={387},
  pages={512-516}
}
The neuregulins (NRGs) are a family of multipotent epidermal-growth-factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new… 
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The N-terminal Region of NTAK/Neuregulin-2 Isoforms Has an Inhibitory Activity on Angiogenesis*
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Results suggest that the active site of NTAK is localized outside of the EGF-like domain but within the N-terminal region, including the Ig-likedomain, of NtaK.
The Neuregulin Family of Genes and their Multiple Splice Variants in Breast Cancer
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All four neuregulin genes are expressed and play an important role in mammary gland development and their presence may affect the efficacy of treatment with endocrine agents or with signal transduction inhibitors directed at the EGF receptor family members.
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