Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

@article{Carraway1997Neuregulin2AN,
  title={Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases},
  author={K. Carraway and J. L. Weber and Michelle J. Unger and J. Ledesma and N. Yu and M. Gassmann and C. Lai},
  journal={Nature},
  year={1997},
  volume={387},
  pages={512-516}
}
The neuregulins (NRGs) are a family of multipotent epidermal-growth-factor-like (EGF-like) factors that arise from splice variants of a single gene. They influence the growth, differentiation, survival and fate of several cell types. We have now discovered a set of new neuregulin-like growth factors, which we call neuregulin-2 (NRG-2): these are encoded by their own gene and exhibit a distinct expression pattern in adult brain and developing heart. Like NRG-1, the EGF-like domain of the new… Expand
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