Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium.

@article{Lai2010Neuregulin1S,
  title={Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium.},
  author={Donna Lai and Xifu Liu and Ariel Forrai and Orit Wolstein and Jan Michalicek and Ishtiaq Ahmed and Alistair N. Garratt and Carmen Birchmeier and Mingdong Zhou and Lynne Hartley and Lorraine Robb and Michael P. Feneley and Diane Fatkin and Richard P. Harvey},
  journal={Circulation research},
  year={2010},
  volume={107 6},
  pages={715-27}
}
RATIONALE The cardiac gene regulatory network (GRN) is controlled by transcription factors and signaling inputs, but network logic in development and it unraveling in disease is poorly understood. In development, the membrane-tethered signaling ligand Neuregulin (Nrg)1, expressed in endocardium, is essential for ventricular morphogenesis. In adults, Nrg1 protects against heart failure and can induce cardiomyocytes to divide. OBJECTIVE To understand the role of Nrg1 in heart development… CONTINUE READING
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