Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons

@article{Ledonne2015Neuregulin1S,
  title={Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons},
  author={Ada Ledonne and Annalisa Nobili and Emanuele Claudio Latagliata and Virve Cavallucci and Ezia Guatteo and Stefano Puglisi-Allegra and Marcello D'Amelio and Nicola Biagio Mercuri},
  journal={Molecular Psychiatry},
  year={2015},
  volume={20},
  pages={959-973}
}
Neuregulin 1 (NRG1) is a trophic factor that has an essential role in the nervous system by modulating neurodevelopment, neurotransmission and synaptic plasticity. Despite the evidence that NRG1 and its receptors, ErbB tyrosine kinases, are expressed in mesencephalic dopaminergic nuclei and their functional alterations are reported in schizophrenia and Parkinson’s disease, the role of NRG1/ErbB signalling in dopaminergic neurons remains unclear. Here we found that NRG1 selectively increases the… CONTINUE READING

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