Neuregulin-1 signalling and antipsychotic treatment

@article{Deng2013Neuregulin1SA,
  title={Neuregulin-1 signalling and antipsychotic treatment},
  author={C. Deng and Bo Pan and M. Engel and X. Huang},
  journal={Psychopharmacology},
  year={2013},
  volume={226},
  pages={201-215}
}
Identifying the signalling pathways underlying the pathophysiology of schizophrenia is an essential step in the rational development of new antipsychotic drugs for this devastating disease. Evidence from genetic, transgenic and post-mortem studies have strongly supported neuregulin-1 (NRG1)–ErbB4 signalling as a schizophrenia susceptibility pathway. NRG1–ErbB4 signalling plays crucial roles in regulating neurodevelopment and neurotransmission, with implications for the pathophysiology of… Expand
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