Neuregulin-1 signalling and antipsychotic treatment

@article{Deng2013Neuregulin1SA,
  title={Neuregulin-1 signalling and antipsychotic treatment},
  author={C. Deng and Bo Pan and M. Engel and X. Huang},
  journal={Psychopharmacology},
  year={2013},
  volume={226},
  pages={201-215}
}
Identifying the signalling pathways underlying the pathophysiology of schizophrenia is an essential step in the rational development of new antipsychotic drugs for this devastating disease. Evidence from genetic, transgenic and post-mortem studies have strongly supported neuregulin-1 (NRG1)–ErbB4 signalling as a schizophrenia susceptibility pathway. NRG1–ErbB4 signalling plays crucial roles in regulating neurodevelopment and neurotransmission, with implications for the pathophysiology of… Expand
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References

SHOWING 1-10 OF 180 REFERENCES
Antipsychotic treatment and neuregulin 1–ErbB4 signalling in schizophrenia
  • Bo Pan, X. Huang, C. Deng
  • Biology, Medicine
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2011
  • 32
Reciprocal signalling between NR2 subunits of the NMDA receptor and neuregulin1 and their role in schizophrenia
  • 41
Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia
  • 142
  • Highly Influential
The neuregulin signaling pathway and schizophrenia: From genes to synapses and neural circuits
  • A. Buonanno
  • Biology, Medicine
  • Brain Research Bulletin
  • 2010
  • 148
  • Highly Influential
Schizophrenia susceptibility pathway neuregulin 1–ErbB4 suppresses Src upregulation of NMDA receptors
  • 139
  • Highly Influential
Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia
  • 522
  • Highly Influential
  • PDF
ErbB4 Localization to Interneurons: Clearer Insights into Schizophrenia Pathology
  • 5
Signaling pathways in schizophrenia: emerging targets and therapeutic strategies.
  • 142
  • Highly Influential
Neuregulin 1 and susceptibility to schizophrenia.
  • 1,565
  • Highly Influential
  • PDF
Neuregulin links dopaminergic and glutamatergic neurotransmission to control hippocampal synaptic plasticity
  • 26
...
1
2
3
4
5
...