Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors.

@article{Kwon2008Neuregulin1RL,
  title={Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors.},
  author={Oh Bin Kwon and Daniel A Paredes and Carmen Mar{\'i}a Padilla Gonz{\'a}lez and J{\"o}rg Neddens and Luis Lizasoain Hern{\'a}ndez and Detlef Vullhorst and Andr{\'e}s Buonanno},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 40},
  pages={15587-92}
}
Neuregulin-1 (NRG-1) is genetically linked with schizophrenia, a neurodevelopmental cognitive disorder characterized by imbalances in glutamatergic and dopaminergic function. NRG-1 regulates numerous neurodevelopmental processes and, in the adult, suppresses or reverses long-term potentiation (LTP) at hippocampal glutamatergic synapses. Here we show that NRG-1 stimulates dopamine release in the hippocampus and reverses early-phase LTP via activation of D4 dopamine receptors (D4R). NRG-1 fails… CONTINUE READING
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