Neuregulin-1 receptor tyrosine kinase ErbB4 is upregulated in midbrain dopaminergic neurons in Parkinson disease.

@article{Depboylu2012Neuregulin1RT,
  title={Neuregulin-1 receptor tyrosine kinase ErbB4 is upregulated in midbrain dopaminergic neurons in Parkinson disease.},
  author={Candan Depboylu and Matthias H{\"o}llerhage and Stefan Schnurrbusch and Patrik Brundin and Wolfgang Hermann Oertel and Andr{\'e} Schrattenholz and G{\"u}nter U. H{\"o}glinger},
  journal={Neuroscience letters},
  year={2012},
  volume={531 2},
  pages={209-14}
}
Previously we demonstrated that systemically administered neuregulin-1-β1, a nerve growth and differentiation factor, passed the blood-brain barrier and accumulated in brain areas with expression of its receptor ErbB4. In substantia nigra (SN), neuregulin-1-β1 phosphorylated ErbB4 and protected dopaminergic neurons in a toxin-based mouse model of Parkinson disease (PD). We studied ErbB4 in the context of human midbrain dopaminergic degeneration in vivo and in vitro. Post-mortem ventral midbrain… CONTINUE READING