Neuregulin-1 impairs the long-term depression of hippocampal inhibitory synapses by facilitating the degradation of endocannabinoid 2-AG.

@article{Du2013Neuregulin1IT,
  title={Neuregulin-1 impairs the long-term depression of hippocampal inhibitory synapses by facilitating the degradation of endocannabinoid 2-AG.},
  author={Huizhi Du and In-Kiu Kwon and Jimok Kim},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 38},
  pages={
          15022-31
        }
}
Endocannabinoids play essential roles in synaptic plasticity; thus, their dysfunction often causes impairments in memory or cognition. However, it is not well understood whether deficits in the endocannabinoid system account for the cognitive symptoms of schizophrenia. Here, we show that endocannabinoid-mediated synaptic regulation is impaired by the prolonged elevation of neuregulin-1, the abnormality of which is a hallmark in many patients with schizophrenia. When rat hippocampal slices were… CONTINUE READING
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Differential distribution of neuregulin in human brain and spinal fluid

  • C Patenaude, CA Chapman, S Bertrand, P Congar, JC Lacaille
  • Brain Res
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