Neuregulin 1 and susceptibility to schizophrenia.

  title={Neuregulin 1 and susceptibility to schizophrenia.},
  author={Hreinn Stef{\'a}nsson and Engilbert Sigurdsson and Valgerdur Steinthorsdottir and Soley Bjornsdottir and Thordur Sigmundsson and Shyamali Ghosh and J{\'o}n Brynj{\'o}lfsson and Steinunn Gunnarsdottir and {\'O}mar {\'I}varsson and Thomas T. t. Chou and {\'O}mar Hjaltason and Birgitta Birgisdottir and Helgi Jonsson and Vala G Gudnadottir and Elsa Gudmundsdottir and Asgeir Bjornsson and Brynj{\'o}lfur Ingvarsson and Andr{\'e}s Ingason and Sigmundur Sigf{\'u}sson and Hronn Hardardottir and Richard P. Harvey and Donna Lai and Ming Dong Zhou and Dani Brunner and Vincent Mutel and Acuna Gonzalo and Greg Lemke and Jesus Sainz and Gardar J{\'o}hannesson and Thorkell Andrésson and Daniel Fannar Gudbjartsson and Andrei Manolescu and Michael L. Frigge and Mark E. Gurney and Augustine Kong and Jeffrey R. Gulcher and Hannes P{\'e}tursson and K{\'a}ri Stef{\'a}nsson},
  journal={American journal of human genetics},
  volume={71 4},
The cause of schizophrenia is unknown, but it has a significant genetic component. Pharmacologic studies, studies of gene expression in man, and studies of mouse mutants suggest involvement of glutamate and dopamine neurotransmitter systems. However, so far, strong association has not been found between schizophrenia and variants of the genes encoding components of these systems. Here, we report the results of a genomewide scan of schizophrenia families in Iceland; these results support… 

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