Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology.

  title={Neuregulin 1 and schizophrenia: genetics, gene expression, and neurobiology.},
  author={Paul J. Harrison and Amanda J. Law},
  journal={Biological psychiatry},
  volume={60 2},
Neuregulin 1 (NRG1) is a leading schizophrenia susceptibility gene. The NRG1 locus on chromosome 8p shows linkage to the disorder, and genetic association has been found between schizophrenia and various non-coding polymorphisms and haplotypes, especially at the 5' end of the NRG1 gene, in many but not all case-control and family studies. NRG1 is a pleiotropic growth factor, important in nervous system development and functioning; roles include the modulation of neuronal migration… CONTINUE READING
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Alterations of neuregulin 1 and ErbB 4 expression in the cerebellum in schizophrenia [ Abstract ]

  • AJ aw, CS Weickert, T Hyde, JE Kleinman, PJ Harrison
  • Schizophr Bull
  • 2005

Expression levels and cellular localization of ErbB receptor mRNAs in the dorsolateral prefrontal cortex in schizophrenia [ Abstract ]

  • S Beltaifa, AJ Law, TM Hyde, B McClintock, MM Herman, PJ Harrison
  • J Neuropathol Exp Neurol
  • 2005
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