Neuregulin 1 and Schizophrenia: Genetics, Gene Expression, and Neurobiology

@article{Harrison2006Neuregulin1A,
  title={Neuregulin 1 and Schizophrenia: Genetics, Gene Expression, and Neurobiology},
  author={Paul J. Harrison and Amanda J. Law},
  journal={Biological Psychiatry},
  year={2006},
  volume={60},
  pages={132-140}
}
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References

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The results of a genomewide scan of schizophrenia families in Iceland show that schizophrenia maps to chromosome 8p, and extensive fine-mapping of the 8p locus and haplotype-association analysis identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia.
Support for involvement of neuregulin 1 in schizophrenia pathophysiology
TLDR
It is suggested that haplotypes across NRG1 and multipleNRG1 variants are involved in schizophrenia, and significant positive correlations were found between SMDF and HRG-beta 2 expression and betweenHRG-gamma and ndf43 expression, suggesting common transcriptional regulation of NRG 1 variants.
Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia
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Findings in the prefrontal cortex of schizophrenic patients suggest that NRG1-erbB signaling is involved in the pathogenesis of schizophrenia, and open new approaches to defining the molecular and cellular basis of schizophrenia in more mechanistic terms.
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This work has reported that neuregulin 1 (NRG1), located in 8p21-12, may be involved in the aetiology of schizophrenia, and other markers located in the middle of NRG1 and associated with schizophrenia, in a Chinese population.
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There was no effect on the NRG-1 mRNA levels of genotype at two SNPs previously associated with schizophrenia, suggesting that these alleles are not functionally responsible for abnormal NRg-1 expression patterns in patients.
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It is tentatively suggested that NRG1 may mediate its effects on schizophrenia susceptibility through functional interaction with erbB4, and that genetic interaction between variants at the two loci increases susceptibility to schizophrenia.
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