Neuregulin 1 and Schizophrenia: Genetics, Gene Expression, and Neurobiology
@article{Harrison2006Neuregulin1A, title={Neuregulin 1 and Schizophrenia: Genetics, Gene Expression, and Neurobiology}, author={Paul J. Harrison and A. Law}, journal={Biological Psychiatry}, year={2006}, volume={60}, pages={132-140} }
Neuregulin 1 (NRG1) is a leading schizophrenia susceptibility gene. The NRG1 locus on chromosome 8p shows linkage to the disorder, and genetic association has been found between schizophrenia and various non-coding polymorphisms and haplotypes, especially at the 5' end of the NRG1 gene, in many but not all case-control and family studies. NRG1 is a pleiotropic growth factor, important in nervous system development and functioning; roles include the modulation of neuronal migration… Expand
428 Citations
Impact of neuregulin-1 on the pathophysiology of schizophrenia in human post-mortem studies
- Biology, Medicine
- European Archives of Psychiatry and Clinical Neuroscience
- 2008
- 21
Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2010
- 109
- PDF
BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia
- Biology, Medicine
- Front. Mol. Neurosci.
- 2017
- 7
Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model
- Psychology, Medicine
- The Journal of Neuroscience
- 2016
- 34
- PDF
Neuregulin-1 and schizophrenia in the genome-wide association study era
- Psychology, Medicine
- Neuroscience & Biobehavioral Reviews
- 2016
- 46
A neuregulin 1 transmembrane domain mutation causes imbalanced glutamatergic and dopaminergic receptor expression in mice
- Biology, Medicine
- Neuroscience
- 2013
- 32
Developmental genetic aspects of schizophrenia, neuregulin-1, and cognition
- Psychology
- 2013
- Highly Influenced
- PDF
Neuregulin-1 mutant mice indicate motor and sensory deficits, indeed few references for schizophrenia endophenotype model
- Psychology, Medicine
- Behavioural Brain Research
- 2017
- 4
Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli
- Psychology, Medicine
- Physiology & Behavior
- 2011
- 33
Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene
- Biology, Medicine
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- 2008
- 104
- PDF
References
SHOWING 1-10 OF 129 REFERENCES
Support for involvement of neuregulin 1 in schizophrenia pathophysiology
- Medicine
- Molecular Psychiatry
- 2005
- 140
- PDF
Neuregulin 1 and susceptibility to schizophrenia.
- Biology, Medicine
- American journal of human genetics
- 2002
- 1,565
- Highly Influential
- PDF
Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia
- Psychology, Medicine
- Nature Neuroscience
- 2004
- 362
A case control and family based association study of the neuregulin1 gene and schizophrenia
- Biology, Medicine
- Journal of Medical Genetics
- 2004
- 118
- PDF
Association between the neuregulin 1 gene and schizophrenia: a systematic review.
- Biology, Medicine
- Schizophrenia bulletin
- 2005
- 121
- PDF
Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia
- Medicine, Psychology
- Molecular Psychiatry
- 2004
- 262
- PDF
Analysis of polymorphisms in AT‐rich domains of neuregulin 1 gene in schizophrenia
- Biology, Medicine
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- 2006
- 43
The involvement of ErbB4 with schizophrenia: Association and expression studies
- Biology, Medicine
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- 2006
- 230
Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
- Biology, Medicine
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- 2006
- 174