Neuregulin 1 and Schizophrenia: Genetics, Gene Expression, and Neurobiology

@article{Harrison2006Neuregulin1A,
  title={Neuregulin 1 and Schizophrenia: Genetics, Gene Expression, and Neurobiology},
  author={Paul J. Harrison and A. Law},
  journal={Biological Psychiatry},
  year={2006},
  volume={60},
  pages={132-140}
}
Neuregulin 1 (NRG1) is a leading schizophrenia susceptibility gene. The NRG1 locus on chromosome 8p shows linkage to the disorder, and genetic association has been found between schizophrenia and various non-coding polymorphisms and haplotypes, especially at the 5' end of the NRG1 gene, in many but not all case-control and family studies. NRG1 is a pleiotropic growth factor, important in nervous system development and functioning; roles include the modulation of neuronal migration… Expand
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