Neuregulin 1 and Schizophrenia: Genetics, Gene Expression, and Neurobiology

  title={Neuregulin 1 and Schizophrenia: Genetics, Gene Expression, and Neurobiology},
  author={Paul J. Harrison and Amanda J. Law},
  journal={Biological Psychiatry},

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Impact of neuregulin-1 on the pathophysiology of schizophrenia in human post-mortem studies
NRG1 isoforms are differentially expressed in relevant brain regions of schizophrenia patients such as the prefrontal cortex and hippocampus and may contribute to pathophysiological processes, but the contribution of NRG1 risk genotypes to expression of isoforms and cognitive or psychotic symptoms in patients remain to be investigated in prospective post-mortem studies.
Common genetic variation in Neuregulin 3 (NRG3) influences risk for schizophrenia and impacts NRG3 expression in human brain
The observations strengthen the evidence that NRG3 is a schizophrenia susceptibility gene, provide quantitative insight intoNRG3 transcription traits in the human brain, and reveal a probable mechanistic basis for disease association.
BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia
A better understanding of Nrg1 in schizophrenia and a potential strategy for using BACE1 cleavage of NRG1 as a unique biomarker for diagnosis, as well as a new therapeutic target, of schizophrenia are provided.
Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model
A novel role for NRG1-IV in learning, memory, and neural circuit formation and a potential neurobiological mechanism for schizophrenia risk are demonstrated; deficits are pharmacologically reversible in adulthood; and p110δ as a target for antipsychotic drug development is highlighted.
Neuregulin-1 and schizophrenia in the genome-wide association study era
Developmental genetic aspects of schizophrenia, neuregulin-1, and cognition
Recent work suggests potentially promising relationships between sequence variation in Neuregulin-1 (NRG1) and both schizophrenia and neurocognitive function. Cognitive deficits are very common in
Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene
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The data suggest that MDGA1 is a new SZ susceptibility gene, and that altered neuronal migration is involved in SZ pathology.


Neuregulin 1 and susceptibility to schizophrenia.
The results of a genomewide scan of schizophrenia families in Iceland show that schizophrenia maps to chromosome 8p, and extensive fine-mapping of the 8p locus and haplotype-association analysis identifies neuregulin 1 (NRG1) as a candidate gene for schizophrenia.
Support for involvement of neuregulin 1 in schizophrenia pathophysiology
It is suggested that haplotypes across NRG1 and multipleNRG1 variants are involved in schizophrenia, and significant positive correlations were found between SMDF and HRG-beta 2 expression and betweenHRG-gamma and ndf43 expression, suggesting common transcriptional regulation of NRG 1 variants.
Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia
Findings in the prefrontal cortex of schizophrenic patients suggest that NRG1-erbB signaling is involved in the pathogenesis of schizophrenia, and open new approaches to defining the molecular and cellular basis of schizophrenia in more mechanistic terms.
A case control and family based association study of the neuregulin1 gene and schizophrenia
This work has reported that neuregulin 1 (NRG1), located in 8p21-12, may be involved in the aetiology of schizophrenia, and other markers located in the middle of NRG1 and associated with schizophrenia, in a Chinese population.
Association between the neuregulin 1 gene and schizophrenia: a systematic review.
There is convincing but not yet compelling evidence for a role for NRG1 in susceptibility to schizophrenia, but in Chinese Han populations, where HAP(ICE) is not found, there is good evidence from several studies of association with other markers in the same region.
Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia
There was no effect on the NRG-1 mRNA levels of genotype at two SNPs previously associated with schizophrenia, suggesting that these alleles are not functionally responsible for abnormal NRg-1 expression patterns in patients.
Analysis of polymorphisms in AT‐rich domains of neuregulin 1 gene in schizophrenia
The findings support a role for NRG1 in SZ in African Americans and suggest that polymorphic differences in regions of the gene that recognize AT‐binding proteins may be a factor in disease pathogenesis.
The involvement of ErbB4 with schizophrenia: Association and expression studies
This study proposes that NRG1 and its receptor ErbB4 are components of a biological pathway, involved in the pathophysiology of schizophrenia, and provides a direct link between Erb B4 and the disease.
Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia
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It is tentatively suggested that NRG1 may mediate its effects on schizophrenia susceptibility through functional interaction with erbB4, and that genetic interaction between variants at the two loci increases susceptibility to schizophrenia.
Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain