Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer.

@article{Park2012Neuregulin1A,
  title={Neuregulin 1-HER axis as a key mediator of hyperglycemic memory effects in breast cancer.},
  author={Jiyoung Park and Venetia Rumnong Sarode and David Michael Euhus and Ralf Kittler and Phillip E Scherer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 51},
  pages={21058-63}
}
Poor outcomes in diabetic patients are observed across a range of human tumors, suggesting that cancer cells develop unique characteristics under diabetic conditions. Cancer cells exposed to hyperglycemic insults acquire permanent aggressive traits of tumor growth, even after a return to euglycemic conditions. Comparative genome-wide mapping of hyperglycemia-specific open chromatin regions and concomitant mRNA expression profiling revealed that the neuregulin-1 gene, encoding an established… CONTINUE READING
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