Neuregulin‐1, a key axonal signal that drives Schwann cell growth and differentiation

@article{Birchmeier2008Neuregulin1AK,
  title={Neuregulin‐1, a key axonal signal that drives Schwann cell growth and differentiation},
  author={Carmen Birchmeier and Klaus-Armin Nave},
  journal={Glia},
  year={2008},
  volume={56}
}
Interactions between neuronal and glial cells are crucial for establishing a functional nervous system. Many aspects of Schwann cell development and physiology are regulated by neuronal signals; possibly the most spectacular is the elaboration of the myelin sheath. An extensive line of research has revealed that one neuronal factor, termed “neuregulin”, promotes Schwann cell growth and survival, migration along the extending axon, and myelination. The versatility of glial responses elicited by… 
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TLDR
Evidence is presented that Schwann cells provide important neurotrophic signals, and also cues that regulate perineurium development and nerve fasciculation, and that these cells serve as a model to study glia–nerve interactions in vivo.
Axonal regulation of myelination by neuregulin 1
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TLDR
This work uses mutant and transgenic mouse lines to show that axonal Neuregulin-1 (Nrg1) signals information about axon size to Schwann cells, and suggests a model by which myelin-forming SchwANN cells integrate axonal Nrg1 signals as a biochemical measure of axonsize.
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TLDR
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TLDR
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TLDR
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TLDR
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