Neuregulin‐1, a key axonal signal that drives Schwann cell growth and differentiation

@article{Birchmeier2008Neuregulin1AK,
  title={Neuregulin‐1, a key axonal signal that drives Schwann cell growth and differentiation},
  author={Carmen Birchmeier and Klaus-Armin Nave},
  journal={Glia},
  year={2008},
  volume={56}
}
Interactions between neuronal and glial cells are crucial for establishing a functional nervous system. Many aspects of Schwann cell development and physiology are regulated by neuronal signals; possibly the most spectacular is the elaboration of the myelin sheath. An extensive line of research has revealed that one neuronal factor, termed “neuregulin”, promotes Schwann cell growth and survival, migration along the extending axon, and myelination. The versatility of glial responses elicited by… 
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Signaling pathways that regulate glial development and early migration—Schwann cells
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This Review focuses on the specific interdependence of axons and Schwann cells in peripheral nerve development that enables axonal outgrowth, Schwann cell lineage progression, radial sorting and, finally, formation and maintenance of the myelin sheath.
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A model in which loss of axonal contact triggers denervated Schwann cells to transiently express NRG1 as an autocrine/paracrine signal that promotes Schwann cell differentiation and remyelination is suggested.
Neuron-glial interactions: Schwann cells
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This review discusses various Schwann cell interactions integral to the proper establishment, spatial arrangement, and function of the PNS, including signals that cascade onto Schwann cells from axons and from the extracellular matrix, bidirectional signals that help to establish the axo‐glial relationship and how Schwann Cells in turn support the axon.
Schwann Cells: Development and Role in Nerve Repair.
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The signals that control the embryonic phase of this process and the organogenesis of peripheral nerves are described and the phenotypic plasticity retained by mature Schwann cells is discussed.
Critical Period of Axoglial Signaling between Neuregulin-1 and Brain-Derived Neurotrophic Factor Required for Early Schwann Cell Survival and Differentiation
TLDR
It is shown that axon-derived soluble NRG1 translocates from axonal to Schwann cell surfaces in the embryonic chick between days 5 and 7, corresponding to the critical period of Schwanncell survival and differentiation.
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TLDR
Understanding the cross talk between neurons and Schwann cells will help to further define the role of glia in preserving axonal integrity and to develop therapeutic strategies for peripheral neuropathies such as CMT1A.
Neuronal Neuregulin 1 type III directs Schwann cell migration
TLDR
It is demonstrated that zebrafish Neuregulin 1 (Nrg1) type III, which signals through ErbB receptors, controls Schwann cell migration in addition to its previously known roles in proliferation and myelination.
Molecular Control of Oligodendrocyte Development
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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