Neuraxial morphine may trigger transient motor dysfunction after a noninjurious interval of spinal cord ischemia: a clinical and experimental study.

@article{Kakinohana2003NeuraxialMM,
  title={Neuraxial morphine may trigger transient motor dysfunction after a noninjurious interval of spinal cord ischemia: a clinical and experimental study.},
  author={Manabu Kakinohana and Martin Marsala and Christopher Carter and J Kenneth Davison and Tony L. Yaksh},
  journal={Anesthesiology},
  year={2003},
  volume={98 4},
  pages={862-70}
}
BACKGROUND A patient underwent repair of a thoracoabdominal aortic aneurysm. Epidural morphine, 4 mg, was given for pain relief. After anesthesia, the patient displayed lower extremity paraparesis. This effect was reversed by naloxone. The authors sought to confirm these observations using a rat spinal ischemia model to define the effects of intrathecal morphine administered at various times after reflow on behavior and spinal histopathology. METHODS Spinal cord ischemia was induced for 6 min… CONTINUE READING